The conservation status of the Dermestidae beetle family within Kazakhstan is examined. Out of 65 species found in the region, 12 are endemics, often restricted to narrow geographic areas and represented by very few specimens. These relict species may be threatened with extinction due to human agricultural activity and overgrazing. Specific biological and ecological data are provided for three endemic species requiring immediate protection: Anthrenus mugodsharicus, Anthrenus kryzhanovskii, and Ctesias tschuliensis.